Indianapolis Colts versus San Francisco 49ers NFL Pro Football Betting Preview

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The Indianapolis Colts will be in for a tough task on Sunday September 22nd as they travel out west to face an angry San Francisco 49ers team from NFL pro football in week three action. The Colts and 49ers will get things started from San Francisco at 4:25PM Eastern Time and CBS will provide the TV broadcast.

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The current odds available for wagering at Oddsmaker, where the bonuses are the best in the business have the home team San Francisco 49ers favored by -10 points with an over under line set at +350 odds. Those who wager on the San Francisco 49ers on the money line will lay -450 odds with the return on the road underdog Indianapolis Colts at +350 odds on the money line.

This is a tough spot for the Colts as they will be facing an angry San Francisco 49ers team that was embarrassed on Sunday Night Football last week by losing to division rival Seattle Seahawks by the score of 29-3 as a +3 point underdog. Indianapolis enters play looking to bounce back from a 24-20 home defeat last week to the Miami Dolphins as a -1 point favorite. In the second half the Colts could not generate offense as they score just three points. After the 49ers were pounded last week at Seattle the team indicated their desire to get into the weight room and get prepared for the Colts this week. An issue for this Colts team has been defending the run game. Last year Indianapolis was pounded by the ground and pound style of the New York Jets losing 35-9 as a +3 ½ point underdog. This is the style of play that the 49ers can play in this spot. They have the offensive line to run between the tacks behind Frank Gore. The 49ers running back is fresh by averaging just 15 yards a carry this season. Last week at Seattle Gore ran only 9 times because San Francisco was playing catch up football down by margin to Seattle. With a division game against the Rams on Thursday night a ground and pound game plan is expected here to shorten the game.

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